Melasma is a complex pigmentation issue triggered by hormones and UV exposure, and treating it requires interrupting the skin’s melanin production. For moderate-to-severe cases, a widely prescribed, FDA-approved option is Tri-Luma, a prescription cream that utilizes a triple-combination of a retinoid, a corticosteroid, and hydroquinone to rapidly fade dark patches. For a highly effective, non-hydroquinone alternative (especially for those taking breaks from hydroquinone therapy), Cyspera Intensive Pigment Corrector uses cysteamine to safely and powerfully lighten hyperpigmentation.