What are the newest treatments for severe eczema?

For decades, severe atopic dermatitis (eczema) and conditions like prurigo nodularis were primarily treated with broad-spectrum topical steroids. Today, dermatology has shifted toward advanced “biologics”—injectable medicines that target the specific immune pathways causing the inflammation and itch from the inside out. Nemluvio is an advanced biologic option specifically designed to block the neuroimmune signals that drive chronic, maddening itch. Another leading systemic treatment in this category is Dupixent, which similarly blocks key inflammatory proteins to heal severe eczema at its root.