Yes, this is a very common and expected reaction known as “retinization.” When starting a powerful topical treatment like Differin Gel or prescription combination therapies, the active medication rapidly accelerates cellular turnover. This brings underlying, microscopic clogged pores to the surface all at once, causing a temporary “purge” or increase in visible breakouts. You may also experience redness and dryness that typically peaks between weeks 2 and 4. It is crucial to push through this phase with a gentle moisturizer, as significant clearing usually occurs after 8 to 12 weeks of consistent use.